On the day Hurricane Katrina hits New Orleans, Daisy Williams (Nee Fuller) is in a New Orleans hospital. At her side is her adult daughter, Caroline. Daisy asks Caroline to read aloud, the diary of Daisy's lifelong friend, Benjamin Button. Benjamin's diary recounts his entire extraordinary life, the main unusual aspect being that he was a recluse, diagnosed with several aging diseases at birth and thus given little chance of survival, but who survived and became younger as time went on. Abandoned by his biological father, Thomas Button, after Benjamin's biological mother died in childbirth, Benjamin was raised by Queenie, a black woman and caregiver at a seniors' home. Daisy's grandmother was a resident at that home, where she first met Benjamin. Despite being separated over the years, Daisy and Benjamin remained in contact throughout their lives, reconnecting in their forties when, in their late teens, they finally matched. Some of the revelations in Benjamin's diary are difficult to read, especially as it relates to the moment of reconnection between Benjamin and Daisy, as Daisy grows older and Benjamin grows younger in his childhood years.