John Constantine, a gifted man bestowed with a gift he never wanted: the ability to perceive the presence of angels and demons within every person. He specializes in investigating mysterious and supernatural cases. He teams up with Los Angeles detective Angela Dodson to investigate the mysterious death of her twin sister, Isabel Dodson, who suffered from mental illness. While alive, Isabel often spoke of supernatural phenomena invisible to others. Meanwhile, in the Mexican desert, the seeds of evil and darkness are waiting for an opportunity to rise.