In "300: Rise of an Empire," Greek general Themistocles leads the charge against the invading Persian forces led by the ruthless naval commander Artemisia. As the Persians aim to conquer Greece, Themistocles rallies an alliance of Greek city-states to engage in naval warfare against the overwhelming Persian fleet. Set against the backdrop of epic sea battles and political intrigue, the film explores the events concurrent with the Battle of Thermopylae depicted in the original "300." Themistocles must navigate treacherous waters, both literal and metaphorical, as he strives to unite Greece and defend its freedom against the might of the Persian Empire.