Many years after the disaster of the panda city, Alice found herself alone; realizing that she had become a liability and could pose a danger to those around her, she struggled to survive and bring down the sinister Umbrella Corporation led by Albert Wesker and Dr. Isaacs, the head researcher. Meanwhile, traversing the Nevada desert and the ruins of Las Vegas, Carlos Olivera, LJ, and the new survivors K-Mart, Claire Redfield, and Nurse Betty must fight to survive the extinction event against hordes of zombies, killer crows, and the most horrifying creatures created as a result of the deadly T-Virus, which has killed millions.