The film tells the story of biologist Davis Okoye who has a close bond with George - a silverback gorilla he has cared for since childhood. An unintended mutation experiment transformed the gorilla into a giant, aggressive monster. Gorillas and other mutated creatures have attacked humans and put humanity in danger of destruction. What will Davis Okoye do to win, not only to prevent a global disaster, but also to save the gorilla that was once his good friend?